Publications

1977
N Macfarlane, B Mathews, and K Dalziel. 1977. “The purification and properties of NADP-dependent isocitrate dehydrogenase from ox-heart mitochondria.” Eur J Biochem, 74, 3, Pp. 553-9.Abstract
The purification of NADP-linked isocitrate dehydrogenase from ox heart mitochondria is described. The molecular weight from gel filtration, sedimentation equilibrium and gel electrophoresis is 90000+/-4000, and there are two subunits in the molecule each of which binds NADPH with enhancement of the coenzyme fluorescence. The amino-acid composition is reported, and the absorption coefficient, A1/280%, estimated from dry weight measurements is 11.8 cm-1.
1976
A Gaucher, RJ Royer, P Netter, MJ Royer-Morrot, G Faure, and J Pourel. 1976. “[Comparison of clinical effect and blood concentration of phenylbutazone during long-term treatment].” Sem Hop, 52, 31-32, Pp. 1723-4.
PV Deshmukh, K Kakinuma, JJ Ameel, KL Rinehart, PF Wiley, and LH Li. 1976. “Letter: Protostreptovaricins I-V.” J Am Chem Soc, 98, 3, Pp. 870-2.
J Samarut and V Nigon. 1976. “Properties and development of erythropoietic stem cells in the chick embryo.” J Embryol Exp Morphol, 36, 2, Pp. 247-60.Abstract
1. When injected into irradiated chickens, haemopoietic stem cells give rise to well-defined erythrocytic colonies in the host marrow. Such stem cells (CFU-M = Colony Forming Unit in Marrow) have been found in different tissue of the chicke embryo (yolk sac, blood, marrow). Analysis of the properties of CFU-M reveals that they represent two classes of stem cells: pluripotent stem cells mainly in adult marrow and erythrocytic-committed stem cells present in yolk sac. 2. Yolk sac contains the main pool of CFU-M during the major part of embryonic life. In the blood of 6-day-old embryo, there are three or four times more CFU-Ms than in the yolk sac; they are no longer detected in the blood after the 16th day of incubation. During development of the marrow, stem cells are actively differentiating and their total number remains the same from 16 days to hatching.
1975
SS Ali and WH Elliott. 1975. “Bile acids. XLVII. 12alpha-Hydroxylation of precursors of allo bile acids by rabbit liver microsomes.” Biochim Biophys Acta, 409, 2, Pp. 249-57.Abstract
Rabbit liver microsomal preparations fortified with 0.1 mM NADPH effectively promote hydroxylation of [3beta-3H]- or [24-14C]allochenodeoxycholic acid or [5alpha,6alpha-3H2]5alpha-cholestane-3alpha,7alpha-diol to their respective 12alpha-hydroxyl derivatives in yields of about 25 or 65% in 60 min. Minor amounts of other products are formed from the diol. The requirements for activity of rabbit liver microsomal 12alpha-hydroxylase resemble those of rat liver microsomes. Of a number of enzyme inhibitors studied only p-chloromercuribenzoate demonstrated a marked ability to inhibit the reaction with either tritiated substrate. There was no difference in the quantity of product produced from the tritiated acid or the 14C-labeled acid. No clear sex difference was found in activity of the enzyme, nor was an appreciable difference noted in activity of the enzyme between mature and immature animals.
K Moroi and T Sato. 1975. “Comparison between procaine and isocarboxazid metabolism in vitro by a liver microsomal amidase-esterase.” Biochem Pharmacol, 24, 16, Pp. 1517-21.
KS Bose and RH Sarma. 1975. “Delineation of the intimate details of the backbone conformation of pyridine nucleotide coenzymes in aqueous solution.” Biochem Biophys Res Commun, 66, 4, Pp. 1173-9.
A Schmoldt, HF Benthe, and G Haberland. 1975. “Digitoxin metabolism by rat liver microsomes.” Biochem Pharmacol, 24, 17, Pp. 1639-41.
AB Makar, KE McMartin, M Palese, and TR Tephly. 1975. “Formate assay in body fluids: application in methanol poisoning.” Biochem Med, 13, 2, Pp. 117-26.
RJ Lefkowitz. 1975. “Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists.” Biochem Pharmacol, 24, 18, Pp. 1651-8.
S Maneksha and TV Harry. 1975. “Lorazepam in sexual disorders.” Br J Clin Pract, 29, 7, Pp. 175-6.
RJ Smith and RG Bryant. 1975. “Metal substitutions incarbonic anhydrase: a halide ion probe study.” Biochem Biophys Res Commun, 66, 4, Pp. 1281-6.
W Haefely, A Kulcsár, and H Möhler. 1975. “Possible involvement of GABA in the central actions of benzodiazepines.” Psychopharmacol Bull, 11, 4, Pp. 58-9.
LB Mekler. 1975. “On the problem of oncogene of tumour viruses.” Acta Virol, 19, 6, Pp. 501-8.Abstract
The approach to the problem of oncogenesis of tumorigenic viruses is compared and analyzed from the position of the Altshtein-Vogt hypothesis and from that of the general theory of oncogenesis advanced by the present author. In contrast to the hypothesis of Altshtein-Vogt dealing mainly with the problem of oncogene origin, the general theory of oncogenesis not only defines concretely the origin of the oncogene and the essence of its product, but also makes it possible to understand why, when and how integration of the oncogene with the genome of the cell leads to the transformation of the cell into a benign cell and when into a malignant tumour cell. An analysis of the essence of the "oncogene position effect" from this standpoint shows that an integration, similar in its mechanism but differing in polarity, of the genome of other viruses with the cell genome should lead to the formation of a corresponding antiviral stable (life-long) immunity or also to the emergence of pseudoautoimmune disease of the type caused by "slow" viruses.
ML Beck, B Freihaut, R Henry, S Pierce, and WL Bayer. 1975. “A serum haemagglutinating property dependent upon polycarboxyl groups.” Br J Haematol, 29, 1, Pp. 149-56.Abstract
A serum agglutinin reactive with red cells in the presence of polycarboxyl groups is reported. It is likely that this represents an additional example of the type of agglutinin previously described as agglutinating red cells in the absence of ionized calcium. Experimental evidence is presented indicating that it is free polycarboxyl groups that potentiate agglutination and that any metal ion, such as calcium, capable of chelating with these groups will prove to be inhibitory.
1975. “V.I. Gavrilov.” Acta Virol, 19, 6, Pp. 510.

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